Protective antibody threshold of RTS,S/AS01 malaria vaccine correlates antigen and adjuvant dose in mouse model

Protective antibody threshold of RTS,S/AS01 malaria vaccine correlates antigen and adjuvant dose in mouse model

Abstract Mouse models are useful for the early down-selection of malaria vaccine candidates. The Walter Reed Army Institute of Research has optimized a transgenic Plasmodium berghei sporozoite challenge model to compare the efficacy of Plasmodium falciparum circumsporozoite protein (CSP) vaccines. G...

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Bibliographic Details
Main Authors: Christopher J. Genito, Katherine Brooks, Alexis Smith, Emma Ryan, Kim Soto, Yuanzhang Li, Lucile Warter, Sheetij Dutta
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00714-x

Internet

https://doi.org/10.1038/s41541-023-00714-x

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