SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer

SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer

Resistance is the major cause of treatment failure and disease progression in non-small cell lung cancer (NSCLC). There is evidence that hypoxia is a key microenvironmental stress associated with resistance to cisplatin, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), and...

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Bibliographic Details
Main Authors: Rui Xu, Xin Luo, Xuan Ye, Huan Li, Hongyue Liu, Qiong Du, Qing Zhai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
non-small cell lung cancer
chemoresistance
SIRT1
PGC-1α
PPAR-γ
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.682762/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.682762/full

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