Butein suppresses PD-L1 expression via downregulating STAT1 in non-small cell lung cancer

Butein suppresses PD-L1 expression via downregulating STAT1 in non-small cell lung cancer

PD-L1 (programmed cell death ligand 1) is frequently up-regulated in tumors and is critical in tumor immune escape. In addition to antibodies that block the interaction between PD-L1 and PD-1 (programmed cell death protein 1), small-molecule compounds that suppress PD-L1 expression also exhibit sign...

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Bibliographic Details
Main Authors: Lin Zhao, Wenxin Zhang, Fengming Luan, Xi Chen, Honghai Wu, Qiaojun He, Qinjie Weng, Ling Ding, Bo Yang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Butein
Natural chalcone compound
PD-L1 transcription
Total STAT1
Immune cell infiltration
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014196

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http://www.sciencedirect.com/science/article/pii/S0753332222014196

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