Mechanism and Effect of Esculetin in an Experimental Animal Model of Inflammatory Bowel Disease

Esculetin is a coumarin derivative with high antioxidant activity. In a rat experimental model of inflammatory bowel disease induced by trinitrobenzenesulfonic acid, esculetin at the dose of 5mg/Kg displayed intestinal anti-inflammatory activity; however, its mechanism of action needs to be elucidat...

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Bibliographic Details
Main Authors: A. Witaicenis, A.C. Luchini, C.A. Hiruma-Lima, S.L. Felisbino, L.A. Justulin, N. Garrido-Mesa, P. Utrilla, J. Gálvez, L.C. Di Stasi
Format: Article
Language:English
Published: SAGE Publishing 2013-05-01
Series:European Journal of Inflammation
Online Access:https://doi.org/10.1177/1721727X1301100213