Dual Blockade of TGF-β Receptor and Endothelin Receptor Synergistically Inhibits Angiotensin II-Induced Myofibroblast Differentiation: Role of AT<sub>1</sub>R/G<sub>αq</sub>-Mediated TGF-β1 and ET-1 Signaling

Dual Blockade of TGF-β Receptor and Endothelin Receptor Synergistically Inhibits Angiotensin II-Induced Myofibroblast Differentiation: Role of AT<sub>1</sub>R/G<sub>αq</sub>-Mediated TGF-β1 and ET-1 Signaling

Angiotensin II (Ang II) upregulates transforming growth factor-beta1 (TGF-β1) and endothelin-1 (ET-1) in various types of cells, and all of them act as profibrotic mediators. However, the signal transduction of angiotensin II receptor (ATR) for upregulation of TGF-β1 and ET-1, and their effectors th...

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Bibliographic Details
Main Authors: Ratchanee Duangrat, Warisara Parichatikanond, Supachoke Mangmool
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
α-SMA
angiotensin II
angiotensin receptor blocker (ARB)
cardiac fibrosis
endothelin-1
endothelin receptor antagonist (ERA)
Online Access:https://www.mdpi.com/1422-0067/24/8/6972

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https://www.mdpi.com/1422-0067/24/8/6972

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