TRK-fused gene (TFG) regulates ULK1 stability via TRAF3-mediated ubiquitination and protects macrophages from LPS-induced pyroptosis

TRK-fused gene (TFG) regulates ULK1 stability via TRAF3-mediated ubiquitination and protects macrophages from LPS-induced pyroptosis

Abstract TRK-fused gene (TFG) is known to be involved in protein secretion and plays essential roles in an antiviral innate immune response. However, its function in LPS-induced inflammation and pyroptotic cell death is still unknown. Here, we reported that TFG promotes the stabilization of Unc-51 l...

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Bibliographic Details
Main Authors: Jian-Hong Shi, Chen Ling, Ting-Ting Wang, Li-Nuo Zhang, Wen-Wen Liu, Yan Qin, Ying-Hui Tan, Nai-Peng Cui, Zhi-Yu Ni
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04539-9

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https://doi.org/10.1038/s41419-022-04539-9

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