Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease

Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's disease

Converging lines of evidence suggest that abnormal accumulation of the kinase Polo-like kinase 2 (PLK2) might play a role in the pathogenesis of Alzheimer's disease (AD), possibly through its role in regulating the amyloid β (Aβ) cascade. In the present study, we investigated the effect of inhi...

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Bibliographic Details
Main Authors: Laura Martínez-Drudis, Razan Sheta, Rémi Pellegrinato, Salma Loukili, Cyntia Tremblay, Frédéric Calon, Serge Rivest, Abid Oueslati
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Polo-like kinase 2
Phosphorylation
Amyloid precursor protein
Tau
3xTg-AD mouse model
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612200225X

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http://www.sciencedirect.com/science/article/pii/S096999612200225X

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