ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

Abstract Background Chromothripsis is an event of genomic instability leading to complex chromosomal alterations in cancer. Frequent long-range chromatin interactions between transcription factors (TFs) and targets may promote extensive translocations and copy-number alterations in proximal contact...

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Bibliographic Details
Main Authors: Chun-Lin Lin, Xi Tan, Meizhen Chen, Meena Kusi, Chia-Nung Hung, Chih-Wei Chou, Ya-Ting Hsu, Chiou-Miin Wang, Nameer Kirma, Chun-Liang Chen, Ching-Hung Lin, Kate I. Lathrop, Richard Elledge, Virginia G. Kaklamani, Kohzoh Mitsuya, Tim H.-M. Huang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Medical Genomics
Subjects:
Luminal subtype breast cancer
Chromosomal rearrangement
ERα
Chromothripsis
Concordant transcription
Druggable target
Online Access:http://link.springer.com/article/10.1186/s12920-020-0729-7

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http://link.springer.com/article/10.1186/s12920-020-0729-7

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