Activation of NOD1 and NOD2 in the development of liver injury and cancer

Activation of NOD1 and NOD2 in the development of liver injury and cancer

Hepatocytes and liver-resident antigen-presenting cells are exposed to microbe-associated molecular patterns (MAMPs) and microbial metabolites, which reach the liver from the gut via the portal vein. MAMPs induce innate immune responses via the activation of pattern recognition receptors (PRRs), suc...

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Bibliographic Details
Main Authors: Naoya Omaru, Tomohiro Watanabe, Ken Kamata, Kosuke Minaga, Masatoshi Kudo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
NOD1
NOD2
hepatocellular carcinoma
microbiota
microbe-associated molecular patterns
pattern recognition receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1004439/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1004439/full

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