Cell-Crossing Functional Network Driven by microRNA-125a Regulates Endothelial Permeability and Monocyte Trafficking in Acute Inflammation

Cell-Crossing Functional Network Driven by microRNA-125a Regulates Endothelial Permeability and Monocyte Trafficking in Acute Inflammation

Opening of the endothelial barrier and targeted infiltration of leukocytes into the affected tissue are hallmarks of the inflammatory response. The molecular mechanisms regulating these processes are still widely elusive. In this study, we elucidate a novel regulatory network, in which miR-125a acts...

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Bibliographic Details
Main Authors: Martin Bernhard Müller, Max Hübner, Lei Li, Stephanie Tomasi, Valena Ließke, David Effinger, Simon Hirschberger, Kristin Pogoda, Markus Sperandio, Simone Kreth
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
microRNA network
inflammation
immune cell trafficking
monocytes
endothelial cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.826047/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.826047/full

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