Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy

Delivery of engineered extracellular vesicles with miR-29b editing system for muscle atrophy therapy

Abstract Muscle atrophy is a frequently observed complication, characterized by the loss of muscle mass and strength, which diminishes the quality of life and survival. No effective therapy except exercise is currently available. In our previous study, repressing miR-29b has been shown to reduce mus...

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Bibliographic Details
Main Authors: Rui Chen, Weilin Yuan, Yongjun Zheng, Xiaolan Zhu, Bing Jin, Tingting Yang, Yuwei Yan, Wanru Xu, Hongjian Chen, Juan Gao, Guoping Li, Priyanka Gokulnath, Gururaja Vulugundam, Jin Li, Junjie Xiao
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Nanobiotechnology
Subjects:
Engineered extracellular vesicles
miR-29b
CRISPR/Cas9
Muscle atrophy
Therapy
Online Access:https://doi.org/10.1186/s12951-022-01508-4

Internet

https://doi.org/10.1186/s12951-022-01508-4

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