Inhibition of Tumor Growth via Systemic siRNA Delivery Using Reducible Bile Acid-Conjugated Polyethylenimine

Inhibition of Tumor Growth via Systemic siRNA Delivery Using Reducible Bile Acid-Conjugated Polyethylenimine

RNA interference (RNAi), mediated by small interfering RNA (siRNA), has been considered as a potential therapeutic agent for cancer owing to its ability to suppress target genes in a sequence-specific manner. In this study, a conjugate of the low molecular weight (MW) polyethylenimine (PEI) (MW 1800...

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Bibliographic Details
Main Authors: Yue Yin, Jung Eun Lee, Nak Won Kim, Jong Han Lee, Su Yeon Lim, E Seul Kim, Ji Won Park, Min Sang Lee, Ji Hoon Jeong
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Polymers
Subjects:
small interfering RNA
deoxycholic acid
stabilized polyplex
disulfide crosslinking
systemic gene therapy
Online Access:http://www.mdpi.com/2073-4360/10/9/953

Internet

http://www.mdpi.com/2073-4360/10/9/953

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