Concurrent CCR7 Overexpression and RelB Knockdown in Immature Dendritic Cells Induces Immune Tolerance and Improves Skin-Graft Survival in a Murine Model

Concurrent CCR7 Overexpression and RelB Knockdown in Immature Dendritic Cells Induces Immune Tolerance and Improves Skin-Graft Survival in a Murine Model

Background/Aims: Skin transplantation aims to cover skin defects but often fails due to immune rejection of the transplantated tissue. Immature dendritic cells (imDCs) induce immune tolerance but have a low migration rate. After stimulation, imDCs transform into mature DCs, which activate immune rej...

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Bibliographic Details
Main Authors: Zhiwei Dong, Yajie Chen, Yuan Peng, Fan Wang, Zichen Yang, Guangtao Huang, Yu Chen, Zhiqiang Yuan, Tongtong Cao, Yizhi Peng
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
imDCs
Treg cells
CCR7
RelB
Immune tolerance
Transplantation
Online Access:http://www.karger.com/Article/FullText/477593

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http://www.karger.com/Article/FullText/477593

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