Study on the Mechanism of Mesaconitine-Induced Hepatotoxicity in Rats Based on Metabonomics and Toxicology Network

Mesaconitine (MA), one of the main diterpenoid alkaloids in Aconitum, has a variety of pharmacological effects, such as analgesia, anti-inflammation and relaxation of rat aorta. However, MA is a highly toxic ingredient. At present, studies on its toxicity are mainly focused on the heart and central...

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Bibliographic Details
Main Authors: Qian Chen, Kai Zhang, Mingjie Jiao, Jiakang Jiao, Dongling Chen, Yihui Yin, Jia Zhang, Fei Li
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/14/7/486