Enhancing the Catalytic Activity of Type II L-Asparaginase from <i>Bacillus licheniformis</i> through Semi-Rational Design

Enhancing the Catalytic Activity of Type II L-Asparaginase from <i>Bacillus licheniformis</i> through Semi-Rational Design

Low catalytic activity is a key factor limiting the widespread application of type II L-asparaginase (ASNase) in the food and pharmaceutical industries. In this study, smart libraries were constructed by semi-rational design to improve the catalytic activity of type II ASNase from <i>Bacillus...

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Bibliographic Details
Main Authors: Yawen Zhou, Linshu Jiao, Juan Shen, Huibing Chi, Zhaoxin Lu, Huawei Liu, Fengxia Lu, Ping Zhu
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
L-asparaginase
protein engineering
saturation mutagenesis
catalytic efficiency
molecular dynamics simulation
Online Access:https://www.mdpi.com/1422-0067/23/17/9663

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https://www.mdpi.com/1422-0067/23/17/9663

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