Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction

Abstract Large‐scale protein signalling networks are useful for exploring complex biochemical pathways but do not reveal how pathways respond to specific stimuli. Such specificity is critical for understanding disease and designing drugs. Here we describe a computational approach—implemented in the...

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Bibliographic Details
Main Authors: Julio Saez‐Rodriguez, Leonidas G Alexopoulos, Jonathan Epperlein, Regina Samaga, Douglas A Lauffenburger, Steffen Klamt, Peter K Sorger
Format: Article
Language:English
Published: Springer Nature 2009-12-01
Series:Molecular Systems Biology
Subjects:
logical modelling
protein networks
signal transduction
Online Access:https://doi.org/10.1038/msb.2009.87

Internet

https://doi.org/10.1038/msb.2009.87

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