VX-765 inhibits pyroptosis and reduces inflammation to prevent acute liver failure by upregulating PPARα expression

VX-765 inhibits pyroptosis and reduces inflammation to prevent acute liver failure by upregulating PPARα expression

Introduction and Objectives: As a fatal clinical syndrome, acute liver failure (ALF) is characterized by overwhelming liver inflammation and hepatic cell death. Finding new therapeutic methods has been a challenge in ALF research. VX-765 is a known pyroptosis inhibitor and has been reported to preve...

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Bibliographic Details
Main Authors: Mingjing Jiao, Jiachao Wang, Wenpeng Liu, Xin Zhao, Yanjun Qin, Chunhuan Zhang, Hongzhu Yin, Caiyan Zhao
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Annals of Hepatology
Subjects:
VX-765
NF-κB
Acute liver failure
Pyroptosis
Peroxisome proliferator-activated receptor α
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268123001862

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http://www.sciencedirect.com/science/article/pii/S1665268123001862

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