Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue

Serglycin Is Involved in TGF-β Induced Epithelial-Mesenchymal Transition and Is Highly Expressed by Immune Cells in Breast Cancer Tissue

Serglycin is a proteoglycan highly expressed by immune cells, in which its functions are linked to storage, secretion, transport, and protection of chemokines, proteases, histamine, growth factors, and other bioactive molecules. In recent years, it has been demonstrated that serglycin is also expres...

Full description

Bibliographic Details
Main Authors: Marta Tellez-Gabriel, Xavier Tekpli, Trine M. Reine, Beate Hegge, Stephanie R. Nielsen, Meng Chen, Line Moi, Lisa Svartdal Normann, Lill-Tove R. Busund, George A. Calin, Gunhild M. Mælandsmo, Maria Perander, Achilleas D. Theocharis, Svein O. Kolset, Erik Knutsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
proteoglycans (PG)
serglycin (SRGN)
transforming growth factor beta (TGF- β)
epithelial-mesenchymal transition (EMT)
breast cancer
tumor infiltrating immune cells
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.868868/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.868868/full

Similar Items