Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation

Regulatory toxicology testing has traditionally relied on in vivo methods to inform decision-making. However, scientific, practical, and ethical considerations have led to an increased interest in the use of in vitro and in silico methods to fill data gaps. While in vitro experiments have the advant...

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Bibliographic Details
Main Authors: David E. Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen, Nicole Kleinstreuer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.864742/full