Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits
The protective effects of oil palm vitamin E and phenolics against atherosclerosis, either singly or in combination, were studied in an atherogenic rabbit model. Rabbits were either fed atherogenic diet only (CTR), or atherogenic diet with vitamin E (VIT E), or atherogenic diet with oil palm phenoli...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-03-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464614000036 |
| _version_ | 1819055286442262528 |
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| author | Che Anishas Che Idris Tilakavati Karupaiah Kalyana Sundram Yew Ai Tan Nagendran Balasundram Soon-Sen Leow Nurrul Shaqinah Nasruddin Ravigadevi Sambanthamurthi |
| author_facet | Che Anishas Che Idris Tilakavati Karupaiah Kalyana Sundram Yew Ai Tan Nagendran Balasundram Soon-Sen Leow Nurrul Shaqinah Nasruddin Ravigadevi Sambanthamurthi |
| author_sort | Che Anishas Che Idris |
| collection | DOAJ |
| description | The protective effects of oil palm vitamin E and phenolics against atherosclerosis, either singly or in combination, were studied in an atherogenic rabbit model. Rabbits were either fed atherogenic diet only (CTR), or atherogenic diet with vitamin E (VIT E), or atherogenic diet with oil palm phenolics (OPP), or atherogenic diet with both vitamin E and oil palm phenolics (VIT E + OPP). Results from lipid profile and antioxidant analyses were not significantly different between groups (p > 0.05). However, fibrous plaques were associated with the CTR group (8.90 ± 5.41%) and these were significantly less (p < 0.05) in the VIT E (2.88 ± 2.01%) and OPP (1.48 ± 4.45%) groups. Fibrous plaques were not detected at all in the VIT E + OPP group. Our findings suggest that oil palm vitamin E and oil palm phenolics individually inhibited atherosclerotic lesion development. However, oil palm vitamin E in combination with oil palm phenolics provided the highest protective effect against development of atherosclerotic lesions. |
| first_indexed | 2024-12-21T13:05:06Z |
| format | Article |
| id | doaj.art-920f5dbab1eb479d8be8bd2bf83bf3f0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-21T13:05:06Z |
| publishDate | 2014-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-920f5dbab1eb479d8be8bd2bf83bf3f02022-12-21T19:03:03ZengElsevierJournal of Functional Foods1756-46462014-03-017541550Oil palm phenolics and vitamin E reduce atherosclerosis in rabbitsChe Anishas Che Idris0Tilakavati Karupaiah1Kalyana Sundram2Yew Ai Tan3Nagendran Balasundram4Soon-Sen Leow5Nurrul Shaqinah Nasruddin6Ravigadevi Sambanthamurthi7Malaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia; National University of Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, MalaysiaNational University of Malaysia, Jalan Raja Muda Aziz, 50300 Kuala Lumpur, MalaysiaMalaysian Palm Oil Council, 2nd Floor, Wisma Sawit, Lot 6, SS6, Jalan Perbandaran, 47301 Kelana Jaya, Selangor, MalaysiaMalaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, MalaysiaMalaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, MalaysiaMalaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, MalaysiaUniversiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaMalaysian Palm Oil Board, 6, Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia; Corresponding author. Tel.: +603 8769 4498; fax: +603 8926 1995.The protective effects of oil palm vitamin E and phenolics against atherosclerosis, either singly or in combination, were studied in an atherogenic rabbit model. Rabbits were either fed atherogenic diet only (CTR), or atherogenic diet with vitamin E (VIT E), or atherogenic diet with oil palm phenolics (OPP), or atherogenic diet with both vitamin E and oil palm phenolics (VIT E + OPP). Results from lipid profile and antioxidant analyses were not significantly different between groups (p > 0.05). However, fibrous plaques were associated with the CTR group (8.90 ± 5.41%) and these were significantly less (p < 0.05) in the VIT E (2.88 ± 2.01%) and OPP (1.48 ± 4.45%) groups. Fibrous plaques were not detected at all in the VIT E + OPP group. Our findings suggest that oil palm vitamin E and oil palm phenolics individually inhibited atherosclerotic lesion development. However, oil palm vitamin E in combination with oil palm phenolics provided the highest protective effect against development of atherosclerotic lesions.http://www.sciencedirect.com/science/article/pii/S1756464614000036AtherosclerosisOil palm phenolicsLipid profilesAntioxidant activity |
| spellingShingle | Che Anishas Che Idris Tilakavati Karupaiah Kalyana Sundram Yew Ai Tan Nagendran Balasundram Soon-Sen Leow Nurrul Shaqinah Nasruddin Ravigadevi Sambanthamurthi Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits Journal of Functional Foods Atherosclerosis Oil palm phenolics Lipid profiles Antioxidant activity |
| title | Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits |
| title_full | Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits |
| title_fullStr | Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits |
| title_full_unstemmed | Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits |
| title_short | Oil palm phenolics and vitamin E reduce atherosclerosis in rabbits |
| title_sort | oil palm phenolics and vitamin e reduce atherosclerosis in rabbits |
| topic | Atherosclerosis Oil palm phenolics Lipid profiles Antioxidant activity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464614000036 |
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