Efficacy and safety of lower dose tenofovir disoproxil fumarate and efavirenz versus standard dose in HIV-infected, antiretroviral-naive adults: a multicentre, randomized, noninferiority trial

Efficacy and safety of lower dose tenofovir disoproxil fumarate and efavirenz versus standard dose in HIV-infected, antiretroviral-naive adults: a multicentre, randomized, noninferiority trial

ABSTRACTReduced doses of antiretroviral (ARV) drugs may lower toxicity while preserving efficacy. We aimed to evaluate the efficacy of reduced doses of both tenofovir disoproxil fumarate (TDF) and efavirenz for the treatment of HIV-1 infection. In this open-label, non-inferiority trial, HIV-1-infect...

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Bibliographic Details
Main Authors: Jun Chen, Rong Chen, Yinzhong Shen, Hongxia Wei, Xicheng Wang, Renfang Zhang, Zhiliang Hu, Ronghui Xie, Qiong Huang, Jiangrong Wang, Li Liu, Tangkai Qi, Zhenyan Wang, Wei Song, Yang Tang, Jianjun Sun, Hongzhou Lu
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Emerging Microbes and Infections
Subjects:
HIV
tenofovir disoproxil fumarate
efavirenz
low dose
non-inferiority
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2020.1752609

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https://www.tandfonline.com/doi/10.1080/22221751.2020.1752609

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