Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 studyResearch in context

Safety and immunogenicity of a synthetic nanoparticle-based, T cell priming peptide vaccine against dengue in healthy adults in Switzerland: a double-blind, randomized, vehicle-controlled, phase 1 studyResearch in context

Summary: Background: Vaccines that minimize the risk of vaccine-induced antibody-dependent enhancement and severe dengue are needed to address the global health threat posed by dengue. This study assessed the safety and immunogenicity of a gold nanoparticle (GNP)-based, multi-valent, synthetic pept...

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Bibliographic Details
Main Authors: Alix Miauton, Régine Audran, Juliette Besson, Hélène Maby-El Hajjami, Maxime Karlen, Loane Warpelin-Decrausaz, Loredana Sene, Sylvain Schaufelberger, Vincent Faivre, Mohamed Faouzi, Mary-Anne Hartley, François Spertini, Blaise Genton
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:EBioMedicine
Subjects:
Dengue vaccine
Dengue virus
T cell immunity
Nanoparticle-based vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423004887

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http://www.sciencedirect.com/science/article/pii/S2352396423004887

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