Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine

Replacing a Palatable High-Fat Diet with a Low-Fat Alternative Heightens κ-Opioid Receptor Control over Nucleus Accumbens Dopamine

Diet-induced obesity reduces dopaminergic neurotransmission in the nucleus accumbens (NAc), and stressful weight loss interventions could promote cravings for palatable foods high in fat and sugar that stimulate dopamine. Activation of κ-opioid receptors (KORs) reduces synaptic dopamine, but contrib...

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Bibliographic Details
Main Authors: Conner W. Wallace, Nari S. Beatty, Sarah A. Hutcherson, Heather A. Emmons, Madison C. Loudermilt, Steve C. Fordahl
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Nutrients
Subjects:
κ-opioid receptors
high-fat diet replacement
dopamine neurotransmission
nucleus accumbens core
novelty-induced hypophagia
elevated plus-maze
Online Access:https://www.mdpi.com/2072-6643/13/7/2341

Internet

https://www.mdpi.com/2072-6643/13/7/2341

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