Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses

Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses

Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo. In this study, we used a targeted modification method for two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic amino acids, and designed and tested new, bacteriol...

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Bibliographic Details
Main Authors: Marek Adam Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzanna Maria Kaźmierczak, Paulina Miernikiewicz, Joanna Marta Majewska, Wiktoria Budziar, Anna Nasulewicz-Goldeman, Daniel C. Nelson, Barbara Owczarek, Krystyna Dąbrowska
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
deimmunization
endolysin
PAL
Cpl-1
epitope engineering
VirScan
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1075774/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1075774/full

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