In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

In vivo human molecular neuroimaging of dopaminergic vulnerability along the Alzheimer’s disease phases

Abstract Background Preclinical and pathology evidence suggests an involvement of brain dopamine (DA) circuitry in Alzheimer’s disease (AD). We in vivo investigated if, when, and in which target regions [123I]FP-CIT-SPECT regional binding and molecular connectivity are damaged along the AD course. M...

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Bibliographic Details
Main Authors: Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Andrea Pilotto, Claudio Liguori, Agostino Chiaravalloti, Valentina Garibotto, Giovanni Battista Frisoni, Marcello D’Amelio, Barbara Paghera, Orazio Schillaci, Nicola Mercuri, Alessandro Padovani, Daniela Perani
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Biomarker
Dopamine
Molecular connectivity
Substantia nigra
Ventral tegmental area
Online Access:https://doi.org/10.1186/s13195-021-00925-1

Internet

https://doi.org/10.1186/s13195-021-00925-1

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