Case Report: Reversible Neurotoxicity and a Clinical Response Induced by BCMA-Directed Chimeric Antigen Receptor T Cells Against Multiple Myeloma With Central Nervous System Involvement

Case Report: Reversible Neurotoxicity and a Clinical Response Induced by BCMA-Directed Chimeric Antigen Receptor T Cells Against Multiple Myeloma With Central Nervous System Involvement

Isolated central nervous system involvement in multiple myeloma (CNS-MM) is rare and carries extremely poor prognosis. Chimeric antigen receptor T cell therapy (CART) targeting B-cell maturation antigen (BCMA) is demonstrated as a promising strategy in MM treatment, but the clinical safety and effic...

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Bibliographic Details
Main Authors: Ying Zhang, Changfeng Zhang, Jin Zhou, Jingren Zhang, Xiaochen Chen, Jia Chen, Pu Wang, Xiuli Sun, Xiaoyan Lou, Wei Qi, Liqing Kang, Lei Yu, Depei Wu, Caixia Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
central nervous system involvement
multiple myeloma
chimeric antigen receptor T cell therpay
neurotoxicity
case report
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.552429/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.552429/full

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