Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring

Polyploidy and Myc Proto-Oncogenes Promote Stress Adaptation via Epigenetic Plasticity and Gene Regulatory Network Rewiring

Polyploid cells demonstrate biological plasticity and stress adaptation in evolution; development; and pathologies, including cardiovascular diseases, neurodegeneration, and cancer. The nature of ploidy-related advantages is still not completely understood. Here, we summarize the literature on molec...

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Bibliographic Details
Main Authors: Olga V. Anatskaya, Alexander E. Vinogradov
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
polyploidy
epigenetic regulation
<i>Myc</i>
chromatin opening
adaptation to stress
gene regulatory network
Online Access:https://www.mdpi.com/1422-0067/23/17/9691

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https://www.mdpi.com/1422-0067/23/17/9691

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