Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.
Due to recent advances of bioinformatics and high throughput sequencing technology, discovery of regulatory noncoding RNAs in bacteria has been increased to a great extent. Based on this bandwagon, many studies searching for trans-acting small noncoding RNAs in streptococci have been performed inten...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2015-03-01
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Series: | Frontiers in Genetics |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00110/full |
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author | Kyu Hong eCho Jeong-Ho eKim |
author_facet | Kyu Hong eCho Jeong-Ho eKim |
author_sort | Kyu Hong eCho |
collection | DOAJ |
description | Due to recent advances of bioinformatics and high throughput sequencing technology, discovery of regulatory noncoding RNAs in bacteria has been increased to a great extent. Based on this bandwagon, many studies searching for trans-acting small noncoding RNAs in streptococci have been performed intensively, especially in the important human pathogen, group A and B streptococci. However, studies for cis-encoded noncoding antisense RNAs in streptococci have been scarce. A recent study shows antisense RNAs are involved in virulence gene regulation in group B streptococcus, S. agalactiae. This suggests antisense RNAs could have important roles in the pathogenesis of streptococcal pathogens. In this review, we describe recent discoveries of chromosomal cis-encoded antisense RNAs in streptococcal pathogens and other low GC Gram (+) bacteria to provide a guide for future studies. |
first_indexed | 2024-04-14T02:57:04Z |
format | Article |
id | doaj.art-9224277dd9504e5ca0bdc17d6d105130 |
institution | Directory Open Access Journal |
issn | 1664-8021 |
language | English |
last_indexed | 2024-04-14T02:57:04Z |
publishDate | 2015-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Genetics |
spelling | doaj.art-9224277dd9504e5ca0bdc17d6d1051302022-12-22T02:16:02ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-03-01610.3389/fgene.2015.00110134045Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens.Kyu Hong eCho0Jeong-Ho eKim1Indiana State UniversityThe George Washington University Medical CenterDue to recent advances of bioinformatics and high throughput sequencing technology, discovery of regulatory noncoding RNAs in bacteria has been increased to a great extent. Based on this bandwagon, many studies searching for trans-acting small noncoding RNAs in streptococci have been performed intensively, especially in the important human pathogen, group A and B streptococci. However, studies for cis-encoded noncoding antisense RNAs in streptococci have been scarce. A recent study shows antisense RNAs are involved in virulence gene regulation in group B streptococcus, S. agalactiae. This suggests antisense RNAs could have important roles in the pathogenesis of streptococcal pathogens. In this review, we describe recent discoveries of chromosomal cis-encoded antisense RNAs in streptococcal pathogens and other low GC Gram (+) bacteria to provide a guide for future studies.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00110/fullnoncoding RNAsregulatory RNAsstreptococciAntisense RNAsGram (+) pathogens |
spellingShingle | Kyu Hong eCho Jeong-Ho eKim Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. Frontiers in Genetics noncoding RNAs regulatory RNAs streptococci Antisense RNAs Gram (+) pathogens |
title | Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. |
title_full | Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. |
title_fullStr | Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. |
title_full_unstemmed | Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. |
title_short | Cis-encoded noncoding antisense RNAs in streptococci and other low GC Gram (+) bacterial pathogens. |
title_sort | cis encoded noncoding antisense rnas in streptococci and other low gc gram bacterial pathogens |
topic | noncoding RNAs regulatory RNAs streptococci Antisense RNAs Gram (+) pathogens |
url | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00110/full |
work_keys_str_mv | AT kyuhongecho cisencodednoncodingantisensernasinstreptococciandotherlowgcgrambacterialpathogens AT jeonghoekim cisencodednoncodingantisensernasinstreptococciandotherlowgcgrambacterialpathogens |