SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression

SIRT3 improved peroxisomes-mitochondria interplay and prevented cardiac hypertrophy via preserving PEX5 expression

The present study identified a novel mechanism underlying the protective effect of Sirtuin 3 (SIRT3) against pathological cardiac hypertrophy, beyond its well-accepted role as a deacetylase in mitochondria. SIRT3 modulates the peroxisomes-mitochondria interplay by preserving the expression of peroxi...

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Bibliographic Details
Main Authors: Minghui Wang, Yanqing Ding, Yuehuai Hu, Zeyu Li, Wenwei Luo, Peiqing Liu, Zhuoming Li
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Redox Biology
Subjects:
SIRT3
PEX5
Cardiomyocyte hypertrophy
Mitochondria-peroxisomes crosstalk
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723000538

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http://www.sciencedirect.com/science/article/pii/S2213231723000538

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