Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia

Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia

Abstract Background In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower extremities. Even before the manifestation of spastic gait, in the prod...

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Bibliographic Details
Main Authors: Christian Lassmann, Winfried Ilg, Tim W. Rattay, Ludger Schöls, Martin Giese, Daniel F. B. Haeufle
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of NeuroEngineering and Rehabilitation
Subjects:
Gait simulation
Spasticity
Hyperreflexia
Prodromal
SPG4
HSP
Online Access:https://doi.org/10.1186/s12984-023-01206-8

Internet

https://doi.org/10.1186/s12984-023-01206-8

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