Ad-Apoptin-hTERTp-E1a Regulates Autophagy Through the AMPK-mTOR-eIF4F Signaling Axis to Reduce Drug Resistance of MCF-7/ADR Cells

Ad-Apoptin-hTERTp-E1a Regulates Autophagy Through the AMPK-mTOR-eIF4F Signaling Axis to Reduce Drug Resistance of MCF-7/ADR Cells

Ad-VT (Ad-Apoptin-hTERTp-E1a) is a type of oncolytic adenovirus with dual specific tumor cell death ability. It can effectively induce cell death of breast cancer cells and has better effect when used in combination with chemotherapy drugs. However, it has not been reported whether Ad-VT reduces the...

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Bibliographic Details
Main Authors: Yaru Li, Yilong Zhu, Jicheng Han, Jinbo Fang, Zhiru Xiu, Shanzhi Li, Wenjie Li, Xia Yang, Ningyi Jin, Lili Sun, Xiao Li, Yiquan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
adriamycin resistance
oncolytic adenovirus
breast cancer
toxicity
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.763500/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.763500/full

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