Hirsutanone Isolated from the Bark of <i>Alnus japonica</i> Attenuates Melanogenesis via Dual Inhibition of Tyrosinase Activity and Expression of Melanogenic Proteins

Hirsutanone Isolated from the Bark of <i>Alnus japonica</i> Attenuates Melanogenesis via Dual Inhibition of Tyrosinase Activity and Expression of Melanogenic Proteins

Hirsutanone (Hir) and oregonin (Ore) are diarylheptanoids isolated from the bark of <i>Alnus japonica</i>. In this study, we investigated the anti-melanogenic activity of Hir and Ore in B16-F1 murine melanoma and normal human epidermal melanocytes (HEMn-DP) and elucidated the mechanisms...

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Bibliographic Details
Main Authors: Takuhiro Uto, Nguyen Huu Tung, Yukihiro Shoyama
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Plants
Subjects:
<i>Alnus japonica</i>
hirsutanone
diarylheptanoid
anti-melanogenesis
tyrosinase
B16-F1 murine melanoma
Online Access:https://www.mdpi.com/2223-7747/11/14/1875

Internet

https://www.mdpi.com/2223-7747/11/14/1875

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