Infection of Human Endothelial Cells with Lassa Virus Induces Early but Transient Activation and Low Type I IFN Response Compared to the Closely-Related Nonpathogenic Mopeia Virus

Infection of Human Endothelial Cells with Lassa Virus Induces Early but Transient Activation and Low Type I IFN Response Compared to the Closely-Related Nonpathogenic Mopeia Virus

Lassa virus (LASV), an Old World arenavirus, is responsible for hemorrhagic fevers in western Africa. The privileged tropism of LASV for endothelial cells combined with a dysregulated inflammatory response are the main cause of the increase in vascular permeability observed during the disease. Mopei...

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Bibliographic Details
Main Authors: Othmann Merabet, Natalia Pietrosemoli, Emeline Perthame, Jean Armengaud, Jean-Charles Gaillard, Virginie Borges-Cardoso, Maïlys Daniau, Catherine Legras-Lachuer, Xavier Carnec, Sylvain Baize
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Viruses
Subjects:
Lassa virus
endothelial cells
viral hemorrhagic fevers
Mopeia virus
pathogenicity
Online Access:https://www.mdpi.com/1999-4915/14/3/652

Internet

https://www.mdpi.com/1999-4915/14/3/652

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