Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.

Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.

The Zcchc11 enzyme is implicated in microRNA (miRNA) regulation. It can uridylate let-7 precursors to decrease quantities of the mature miRNA in embryonic stem cell lines, suggested to mediate stem cell maintenance. It can uridylate mature miR-26 to relieve silencing activity without impacting miRNA...

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Bibliographic Details
Main Authors: Matthew R Jones, Matthew T Blahna, Elyse Kozlowski, Kori Y Matsuura, Joseph D Ferrari, Samantha A Morris, John T Powers, George Q Daley, Lee J Quinton, Joseph P Mizgerd
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3510031?pdf=render

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http://europepmc.org/articles/PMC3510031?pdf=render

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