Celastrol Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular Inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway

Celastrol Alleviates Chronic Obstructive Pulmonary Disease by Inhibiting Cellular Inflammation Induced by Cigarette Smoke via the Ednrb/Kng1 Signaling Pathway

Chronic obstructive pulmonary disease (COPD) is a debilitating disease caused by chronic exposure to cigarette smoke (CS). Celastrol is a pentacyclic triterpenoid compound exhibits potent antioxidant and anti-inflammatory activities. Also it is presently known to protect against liver damage induced...

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Bibliographic Details
Main Authors: Ke Shi, Xi Chen, Bin Xie, Sha Sha Yang, Da Liu, Gan Dai, Qiong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
Ednrb
Kng1
chronic obstructive pulmonary disease
cigarette smoke exposure
inflammation
Celastrol
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01276/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01276/full

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