The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation

The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation

The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood. Here, we show that the T60 variant of CARD8, but not the...

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Bibliographic Details
Main Authors: Zhihao Xu, Shasha Deng, Yuluo Huang, Yunru Yang, Liangqi Sun, Hanyuan Liu, Dan Zhao, Weihong Zeng, Xueying Yin, Peiyi Zheng, Yingying Wang, Muziying Liu, Weidong Zhao, Tsan Sam Xiao, Ying Zhou, Tengchuan Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
NLRP1 inflammasome
CARD8
death domain superfamily
CARD
autoinflammatory diseases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047922/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047922/full

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