Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice

Isthmin-1 attenuates allergic Asthma by stimulating adiponectin expression and alveolar macrophage efferocytosis in mice

Abstract Background Allergic asthma is a common respiratory disease that significantly impacts human health. Through in silico analysis of human lung RNASeq, we found that asthmatic lungs display lower levels of Isthmin-1 (ISM1) expression than healthy lungs. ISM1 is an endogenous anti-inflammatory...

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Bibliographic Details
Main Authors: Jong Huat Tee, Udhaya Vijayakumar, Mahalakshmi Shanmugasundaram, Terence Y. W. Lam, Wupeng Liao, Yuansheng Yang, W. S. Fred Wong, Ruowen Ge
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Respiratory Research
Subjects:
Isthmin-1
Asthma
Adiponectin
Efferocytosis
Necroptosis
Alveolar macrophage
Online Access:https://doi.org/10.1186/s12931-023-02569-1

Internet

https://doi.org/10.1186/s12931-023-02569-1

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