Sex-differential RXRα gene methylation effects on mRNA and protein expression in umbilical cord of the offspring rat exposed to maternal obesity

Sex-differential RXRα gene methylation effects on mRNA and protein expression in umbilical cord of the offspring rat exposed to maternal obesity

Maternal obesity (MO) induces negative consequences in the offspring development. Adiposity phenotype is associated with maternal diet at early pregnancy and DNA methylation marks in the RXRα promotor at birth. Glucocorticoids play an important role in the regulation of metabolism through the activa...

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Bibliographic Details
Main Authors: Erika Chavira-Suárez, Luis Antonio Reyes-Castro, Itzel Ivonn López-Tenorio, Lilia Vargas-Hernández, Guadalupe L. Rodríguez-González, Roberto Chavira, Paola Zárate-Segura, Aaron Domínguez-López, Felipe Vadillo-Ortega, Elena Zambrano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
DNA methylation
sexual dimorphism
maternal diet
corticosterone
estradiol
steroid hormones
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.892315/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.892315/full

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