Serial ultra‐deep sequencing of circulating tumor DNA reveals the clonal evolution in non‐small cell lung cancer patients treated with anti‐PD1 immunotherapy

Serial ultra‐deep sequencing of circulating tumor DNA reveals the clonal evolution in non‐small cell lung cancer patients treated with anti‐PD1 immunotherapy

Abstract Background Immune‐therapy with anti‐PD1 inhibitors, such as pembrolizumab, is revolutionizing the treatment of non‐small cell lung cancers (NSCLC). However, identifying patients for the potential therapeutic response and predicting therapy resistance and early relapse remains a challenge. M...

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Bibliographic Details
Main Authors: Li Li, Yubo Wang, Weiwei Shi, Mengxiao Zhu, Zhulin Liu, Nuo Luo, Yanwu Zeng, Yong He
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Cancer Medicine
Subjects:
ctDNA
distant metastasis
lung cancer
maximum somatic allele frequency
pembrolizumab
Online Access:https://doi.org/10.1002/cam4.2632

Internet

https://doi.org/10.1002/cam4.2632

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