Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells

Cdk1 Phosphorylates SPAT-1/Bora to Promote Plk1 Activation in C. elegans and Human Cells

The conserved Bora protein is a Plk1 activator, essential for checkpoint recovery after DNA damage in human cells. Here, we show that Bora interacts with Cyclin B and is phosphorylated by Cyclin B/Cdk1 at several sites. The first 225 amino acids of Bora, which contain two Cyclin binding sites and th...

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Bibliographic Details
Main Authors: Yann Thomas, Luca Cirillo, Costanza Panbianco, Lisa Martino, Nicolas Tavernier, Françoise Schwager, Lucie Van Hove, Nicolas Joly, Anna Santamaria, Lionel Pintard, Monica Gotta
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303205

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http://www.sciencedirect.com/science/article/pii/S2211124716303205

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