Molecular Dynamics Simulation of Drug Solubilization Behavior in Surfactant and Cosolvent Injections

Surfactants and cosolvents are often combined to solubilize insoluble drugs in commercially available intravenous formulations to achieve better solubilization. In this study, six marketed parenteral formulations with surfactants and cosolvents were investigated on the aggregation processes of micel...

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Bibliographic Details
Main Authors: Meiqi He, Wenwen Zheng, Nannan Wang, Hanlu Gao, Defang Ouyang, Zunnan Huang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/14/11/2366