Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral bioavailability of Asenapine maleate

Exploring peptide dendrimers for intestinal lymphatic targeting: formulation and evaluation of peptide dendrimer conjugated liposomes for enhancing the oral bioavailability of Asenapine maleate

Abstract Asenapine maleate (ASPM) is a second-generation atypical antipsychotic that is approved for treating acute schizophrenia and bipolar disorder in adults by the US FDA. The major downside of ASPM therapy is rapid, extensive first-pass hepatic metabolism following its oral administration with...

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Bibliographic Details
Main Authors: Ajjappla Basavaraj Shreya, Abhijeet Pandey, Sanjay Kulkarni, K Vijaya Bhaskar, Harendra S. Parekh, Srinivas Mutalik
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Peptide dendrimer
Liposome
Lymphatic targeting
Schizophrenia
Online Access:https://doi.org/10.1038/s41598-024-79372-5

Internet

https://doi.org/10.1038/s41598-024-79372-5

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