Crystal structures of the catalytic domain of human soluble guanylate cyclase.

Soluble guanylate cyclase (sGC) catalyses the synthesis of cyclic GMP in response to nitric oxide. The enzyme is a heterodimer of homologous α and β subunits, each of which is composed of multiple domains. We present here crystal structures of a heterodimer of the catalytic domains of the α and β su...

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Bibliographic Details
Main Authors: Charles K Allerston, Frank von Delft, Opher Gileadi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3591389?pdf=render