Serotonergic Modulation of Nigrostriatal and Mesolimbic Dopamine and Motor/Exploratory Behaviors in the Rat

Serotonergic Modulation of Nigrostriatal and Mesolimbic Dopamine and Motor/Exploratory Behaviors in the Rat

Purpose: The 5-HT2A receptor (R) is known to modulate dopamine (DA) release in the mammalian brain. Altanserin (ALT) and 2,5-dimethoxy-4-iodoamphetamine (DOI) act as 5-HT2AR antagonist and agonist, respectively. In the present study, we assessed the effects of ALT and DOI on motor and exploratory be...

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Bibliographic Details
Main Authors: Susanne Nikolaus, Hans-Jörg Wittsack, Christina Antke, Markus Beu, Hubertus Hautzel, Cvetana Decheva, Eduards Mamlins, Yuriko Mori, Joseph P. Huston, Gerald Antoch, Hans-Wilhelm Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neuroscience
Subjects:
D2/3 receptor
[123I]IBZM
5-HT2A receptor
altanserin
2,5-dimethoxy-4-iodoamphetamine
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.682398/full

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https://www.frontiersin.org/articles/10.3389/fnins.2021.682398/full

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