The MYC-YBX1 Circuit in Maintaining Stem-like Vincristine-Resistant Cells in Rhabdomyosarcoma

The MYC-YBX1 Circuit in Maintaining Stem-like Vincristine-Resistant Cells in Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that causes significant devastation, with no effective therapy for relapsed disease. The mechanisms behind treatment failures are poorly understood. Our study showed that treatment of RMS cells with vincristine led to an increase in CD133-pos...

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Bibliographic Details
Main Authors: Madeline Fritzke, Kenian Chen, Weiliang Tang, Spencer Stinson, Thao Pham, Yadong Wang, Lin Xu, Eleanor Y. Chen
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
rhabdomyosarcoma
stem cells
therapy resistance
MYC
YBX1
zebrafish
Online Access:https://www.mdpi.com/2072-6694/15/10/2788

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https://www.mdpi.com/2072-6694/15/10/2788

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