Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

Hepatocyte-specific HDAC3 ablation promotes hepatocellular carcinoma in females by suppressing Foxa1/2

Abstract Background Hepatocellular carcinoma (HCC), the most common primary liver cancer, prevails mainly in males and has long been attributed to androgens and higher circumstantial levels of interleukin-6 (IL-6) produced by resident hepatic macrophages. Methods Constitutively hepatocyte-specific h...

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Bibliographic Details
Main Authors: Yahong Xu, Yongjie Zhu, Zhenru Wu, Shengfu Li, Mingyang Shao, Qing Tao, Qing Xu, Yuwei Chen, Yuke Shu, Menglin Chen, Yongjie Zhou, Yujun Shi
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Cancer
Subjects:
HDAC3
HCC
Sex difference
IL-6
Foxa1
Foxa2
Online Access:https://doi.org/10.1186/s12885-023-11393-1

Internet

https://doi.org/10.1186/s12885-023-11393-1

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