AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway

AG1024, an IGF-1 receptor inhibitor, ameliorates renal injury in rats with diabetic nephropathy via the SOCS/JAK2/STAT pathway

Insulin-like-growth factor-1 (IGF-1) is the ligand for insulin-like growth factor-1 receptor (IGF-1R), and the roles of IGF-1/IGF-1R in diabetic nephropathy (DN) are well-characterized previously. However, the biological functions of AG1024 (an IGF-1R inhibitor) in DN remain unknown. This study inve...

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Bibliographic Details
Main Authors: Liu Jianhua, Zhang Yun, Liu Min, Shi Feng, Cheng Bo
Format: Article
Language:English
Published: De Gruyter 2023-04-01
Series:Open Medicine
Subjects:
diabetic nephropathy
igf-1 receptor
ag1024
fibrosis
inflammation
socs
Online Access:https://doi.org/10.1515/med-2023-0683

Internet

https://doi.org/10.1515/med-2023-0683

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