Omega-3 Fatty Acids Modulate Weibel-Palade Body Degranulation and Actin Cytoskeleton Rearrangement in PMA-Stimulated Human Umbilical Vein Endothelial Cells

Omega-3 Fatty Acids Modulate Weibel-Palade Body Degranulation and Actin Cytoskeleton Rearrangement in PMA-Stimulated Human Umbilical Vein Endothelial Cells

Long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) produce cardiovascular benefits by improving endothelial function. Endothelial cells store von Willebrand factor (vWF) in cytoplasmic Weibel-Palade bodies (WPBs). We examined whether LC n-3 PUFAs regulate WPB degranulation using cultured...

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Bibliographic Details
Main Authors: Corinna S. Bürgin-Maunder, Peter R. Brooks, Fraser D. Russell
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Marine Drugs
Subjects:
omega-3 fatty acids
von willebrand factor
weibel-palade bodies
endothelial function
actin cytoskeleton
Online Access:http://www.mdpi.com/1660-3397/11/11/4435

Internet

http://www.mdpi.com/1660-3397/11/11/4435

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