An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

An in vitro cytotoxicity of glufosfamide in HepG2 cells relative to its nonconjugated counterpart

Abstract Background Glufosfamide (β-d-glucosylisophosphoramide mustard, GLU) is an alkylating cytotoxic agent in which ifosforamide mustard (IPM) is glycosidically linked to the β-d-glucose molecule. GLU exerted its cytotoxic effect as a targeted chemotherapy. Although, its cytotoxic efficacy in a n...

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Bibliographic Details
Main Authors: Doaa E. Ahmed, Fatma B. Rashidi, Heba K. Abdelhakim, Amr S. Mohamed, Hossam M. M. Arafa
Format: Article
Language:English
Published: SpringerOpen 2021-08-01
Series:Journal of the Egyptian National Cancer Institute
Subjects:
Glufosfamide HepG2 cytotoxicity
Ifofosfamide (IFO)
Bcl-2
Caspase-9
Mitochondrial membrane potential
Online Access:https://doi.org/10.1186/s43046-021-00080-6

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