Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects

Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects

Cancer stem cells (CSCs) with their self-renewal ability are accepted as cells which initiate tumors. CSCs are regarded as interesting targets for novel anticancer therapeutic agents because of their association with tumor recurrence and resistance to conventional therapies, including radiotherapy a...

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Bibliographic Details
Main Authors: Javad Masoumi, Abdollah Jafarzadeh, Jalal Abdolalizadeh, Haroon Khan, Jeandet Philippe, Hamed Mirzaei, Hamid Reza Mirzaei
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Chimeric antigen receptor T cell
Cancer stem cell
Immunotherapy
Tumor associated antigens
Combination therapy
Off-tumor toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383520308492

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http://www.sciencedirect.com/science/article/pii/S2211383520308492

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